生醫奈微米工程

臺北科技大學 115-1 學期課程，課號 363575。

課程大綱

奈微米工程於生物醫學之應用日趨重要，量測與操作工具的開發與實際的生醫應用對象的大小尺寸具有密切的相關性，對於生物系統的充份瞭解是工程表現的重要過程之一。在此課程中將配合本校實驗室目前之相關研究設備進行原理講解與應用討論，包括之項目將由分子、細胞到組織之感測、分析與操縱。選修學生須依下列重點：奈微米生醫感測系統、奈米生醫材料、奈米生醫光電以及實驗室晶片等領域選擇期中期末報告之題目與計畫內容，主要要求在尋求創新思考方向，以求在原理或應用上的突破，積極推動跨領域與技術先進之整合性研究。 The application of nano-micron engineering in biomedicine is becoming more and more important. The development of measurement and operation tools is closely related to the size of actual biomedical application objects. A full understanding of biological systems is one of the important processes of engineering performance. In this course, the principle explanation and application discussion will be carried out with the current research equipment in our laboratory, including the sensing, analysis and manipulation of molecules. Elective students should choose the topics and project content of the mid-term report in the fields of nano-micron biomedical sensing system, nano-biomedical materials, nano-biomedical optoelectronics, and laboratory chips. The main requirement is to seek innovative thinking , In order to seek breakthroughs in principles or applications, and actively promote integrated research across fields and advanced technologies.

課程進度

Week Topics 1 Introduction of course, Grouping 2 CMOS MEMS Overview, Introduction of CIC for Chip design 3 Introduction of BioMEMS and Chip design 4 Introduction of nano-bio-chip and Chip design 5 Review in Micro & Nano Technologies and Chip design 6 Project proposal presentation 7 cantilever biosensor I 8 cantilever biosensor II 9 Affinity principle and SPR and ELISA 10 Paper based sensors 11 Electrochemical sensor 12 Bio Thin film coating technology 13 TIRFM 14 MOCSER 15 FET and electrochemical biosensors 16 Biosensor telecare overview 17 Final Project Presentation and demo 18 Final thesis report deadline Lab Project List: Project 1 Soft lithography (fabrication) Mixing (Testing) PDMS & Microscale Mixing, Project 2 3D Printing (fabrication) Hydrodynamic Focusing or chemical reaction (Testing) 3D Printing based microfluidics Project 3 Paper based sensor (fabrication) Chemical or biological (testing) Paper based sensors Project 4 Microcantilever sensor (characterization, testing) Microcantilever Chemical Sensor

評量方式

1. Grading: Lab project: 70% 〇 Team work 25 % 〇 Project proposal presentation 30% 〇 Project final presentation 15 % 2. Q&A in class: 15% 3. Final thesis report : 15%

教材

【遵守智慧財產權觀念，請使用正版教科書，不得使用非法影印教科書】 使用外文原文書：是 Class slide handout. BioMEMS, Technologies and Applications By Wanjun Wang (ME, LSU), and Steven A. Soper (Chem. LSU)