蛋白質醣類學特論

臺北科技大學 114-2 學期課程，課號 356477。

課程大綱

The course is designed to teach upper level undergraduate students and graduate students about the recent advances in protein science and glycobiology with specific application in medical and biotechnological industries. This course provides a comprehensive understanding of proteomics, emphasizing the revolutionary impact of AlphaFold on protein structure prediction. Students will explore proteomics techniques, data analysis, and practical applications, with hands-on experience using AlphaFold. Course Goals includes: 1. Understand the principles of proteomics and protein biochemistry. 2. Gain proficiency in experimental and computational proteomics techniques. 3. Explore the functionalities and applications of AlphaFold in predicting protein structures. 4. Apply knowledge to real-world biological problems.

課程進度

Week 1: Introduction to Proteins and Proteomics- Nobel 2024 Week 2: Protein Biochemistry I Week 3: Protein Biochemistry II Week 4: Hierarchical structure of proteins I Week 5: Hierarchical structure of proteins II Week 6: Protein domains and motifs. Week 7: Functional roles of proteins: Enzymes, transport, signaling, and structural proteins. Week 8: Introduction to AlphaFold Week 9: Midterm (30%) Week 10: AlphaFold: History and development (key achievements) Week 11: Overview of machine learning in structural biology Week 12: Limitations of AlphaFold Week 13: Unix Basic, PDB database, Structural analysis tools Week 14 Training data and methods I. Week 15: EMBL platform introduction Week 16-17: Training data and methods II. Week 18: Final exam (30%)

評量方式

Evaluation: Homework (20%), Mid-term (30 %), Final case report (30%), Class attendance (20 %) ------------------------------------------------------- Mid-term presentation: PPT file Final exam is a summary report on using AlphaFold for protein structure prediction

教材

【遵守智慧財產權觀念，請使用正版教科書，不得使用非法影印教科書】 使用外文原文書：是 Varki A, Cummings RD, Esko JD, et al., editors. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Website: https://www.ncbi.nlm.nih.gov/books/NBK579918/